Daftar Guru SMK Muhammadiyah 1 Prambanan Klaten (MUTU+)
| No | Nama | L/P | NBM | Jabatan | Guru Mapel |
| 1 | Drs. Sukardi | L | 700.506 | Kepala Sekolah | Agama |
| 2 | Nurhayati, S.Pd | P | 957.658 | Waka Kurikulum | Prod. Keuangan |
| 3 | Danang Apriadi, S.Pd | L | 1184368 | Waka Kesiswaan | BK |
| 4 | Fajar Indriyawati, S.Pd | P | 983.819 | Waka Sarpras/Wali X Farmasi | Matematika |
| 5 | Dra.Hj. Yuani Aris Widiastuti | P | 723.069 | Kepala Perpus | Bhs. Indonesia |
| 6 | Rumiyati, SE | P | 888.706 | Kaproli AD | Produktif. AP |
| 7 | |||||
| 8 | Dra. Siti Harjani | P | 719.758 | Guru | Produktif. AP |
| 9 | |||||
| 10 | Sardiyana, S.Pd | L | 888.392 | Guru | Bhs. Indonesia |
| 11 | Wahyu Cahyani Wulan, S.Si | P | 1044182 | Wali XII AD | Matematika |
| 12 | Eka Ludiati, S.Far | P | Kaproli Farmasi | Produktif Farmasi | |
| 13 | Ritaningsih, S.Pd | P | 913.098 | Wali XI KU | Bhs. Inggris |
| 14 | Ghozali Nur Cahyo, S.kom | L | Kaproli TKJ | Prod .TKJ | |
| 15 | Sukirdi, S.Pd | L | 629.964 | Guru | Matematika |
| 16 | Drs. Suratmin | L | 888.393 | Guru | PPKn |
| 17 | Septiani Yulian Herwindha, SE | P | 1005.784 | Kaproli KU / Wali XII KU | Prod. Keuangan |
| 18 | Anindra Zulfa, S.Psi | P | 1067010 | Guru / Koordinator BK / Wali Kelas X KU | BK |
| 19 | Sulandari, S.Pd.I | P | Wali X TKJ | Agama | |
| 20 | Munir Fathoni, S.Pd | L | 1186183 | Wali XII TKJ | Ilmu Olah Raga |
| 21 | Suharni, S.Pd | P | Guru / Wali X AD | Bhs. Jawa | |
| 22 | Pitriana, S.Kom | P | Guru / Wali XI TKJ | Prod. TKj | |
| 23 | Tommy Kembara Primawati | P | Guru / Wali XII FARMASI | IPA | |